Pfizer is Getting Their A** Handed to Them Yet Again
The FDA too, especially if they don't pull the "vaccines" off the market immediately.
Yesterday some woke researchers tried their best to downplay results from a study that showed there was ribosomal frame shifting in the mod RNA vaccines we were mandated to take (or forced to take at the threat of losing our jobs).
This sounds terribly esoteric but it is, in fact, very understandable; at least the simple explanation I’m going to give you.
There are 20 amino acids. You’ve heard of some of them before Arginine, Alanine, etc. These amino acids are the building blocks of our proteins.
They are coded for by sets of three nucleotides, of which there are four different varieties, in our DNA and then RNA (after transcription from DNA) called “codons”. There is a strict mapping from those codons to specific amino acids. However, the mapping “strictness” doesn’t apply in reverse. This is because there are 64 different possible codons and, like I said, only 20 different amino acids. Arginine has 6 different codons that map to it (and this is how myself and others realized the virus was made in a lab and did not get into the human population through natural zoonotic spillover (along with even more powerful evidence)).
There are 64 ways of taking 4 distinct things and arranging them in unique sets of three because at each position in the set of three, one of four things can be present and 4 x 4 x 4 = 64.
Remember when you were pedaling hard and fast on a rich friend’s 10-speed bicycle and something went, “thunk” and you went from 3rd gear to 5th? Well the subject of the disastrous paper that came out yesterday centers on the phenomenon of ribosomal frame shifting. I’m going to tell you what that implies in a second but lets review the transcription to translation mechanism briefly for those subscribers to First Principles who haven’t watched the immunology primer from my video, “STOP THE SARS-2 STUPIDITY, PLEASE! of October, 2020.
DNA gets transcribed into mRNA in the nucleus of the cell. The mRNA gets transported into the cytoplasm where it joins up with a ribosome- that thing that looks like an “8” to form a thing that looks like an 8 with a ticker tape running through the middle of it. The ribosome reads the codons on the mRNA- the ticker tape- and matches them with the corresponding “anticodon” on yet another type of RNA called “transfer RNA” that has attached to it the unique amino acid that corresponds to its anticodon (and thus codon because there are rules that say which nucleotides match up (anti-codon to codon) with which others, specifically “A goes with U” and “C goes with G”).
This happens over and over again from the Initiating codon which, if I remember correctly is AUG- isn’t it funny how you remember little things from 40 years ago?-, to one of the stop codons which I don’t remember specifically; just that there were three of them..
Ok so to check the artist quickly, you can see lysine’s anticodon of UUU corresponds to the AAA codon on the mRNA. Before that, tryptophan is there in the amino acid chain showing an anticodon of ACC which means its codon should be UGG which it is. It’s where it should be, preceding the AAA on the mRNA shown. Do you see the AUG that’s mixed up in all that, preceding the AAA by a single nucleotide, G? Keep that in the back of your mind for a little bit.
There can be thousands of codons mapping to unique amino acids making one specific protein, the shape of which determines its function in the body, that shape being determined by how the thing folds on itself and the associated electric charges in the form of electron clouds surrounding the whole thing. There’s a lot of quantum mechanics going on here so we’ll end this part of the discussion at this point and just agree to pretend there’s some kind of lock and key mechanism between the protein we just synthesized and its receptor protein out there in the body’s cells waiting for it to come and interact for a specific purpose.
Ribosomal frame shifting is just what it sounds like and my analogy with the 10 speed bicycle skipping a gear is a pretty good one for showing how screwed up this can get except that it’s much, much worse when talking about this happening with RNA. (If the 10 speed skips, say, gear 2, gears 3 through 10 should not be affected. They’ll still work like they’re supposed to.
Not so with mRNA. If one of the nucleotides gets skipped over, every single codon will be wrong from that point on (but probably not every amino acid because of the “21 things described 64 ways” issue ). If three get skipped over, only one amino acid will be affected. I guess it will be missing from what the final protein should have been. Maybe that will make a big difference in the protein, maybe not. In fact, if any multiple of three get skipped over, you’ll have only a small disruption to the sequence of amino acids. It might or might not be significant to the functioning of the protein.
This is much easier to see if we use everyday language. Suppose you have a sentence that reads,
The cat and dog see the man.
If you shift the frame over one letter (nucleotide) you’ll get
Hec ata ndd ogs eet hem
which is total gibberish
See how dangerous frame shifting can be? By skipping a single nucleotide (a +1 or -1 frameshift), you’ll change every amino acid (almost) and you’ll get some start and stop codons in the wrong places and you’re going to make completely different proteins.
What will our sentence look like if we skip three letters?
It might not make much difference at all as in this case
“The cat and dog see man” or “Cat and Dog see the man” or it could mean a lot as in
The cat and dog the man (see the man?, bite the man? like the man? eat the man?
Any way you cut it, accidental frame shifting is not good and can lead to bizarre and potentially-dangerous or toxic proteins being made. or like I asked you to keep in the back of your head, getting a start or stop codon where you’re not supposed to. Imagine if there was a +1 frame shift in the mRNA coding for the translation of insulin in the islets of Langerhans cells of the pancreas. One certainty is that you’d have diabetes in that patient because you won’t be making anything that works like insulin.
But another problem might even be more serious. What happens when that islet cell makes a bizarre protein that is not self? It’s going to get presented on the surface of those cells after getting chopped up into peptides in the usual fashion and if it’s not a self peptide, a CD8 T killer cell is going to come along and destroy that cell by the process of apoptosis and there’s going to be organ damage.
What does all of this have to do with Pfizer and the FDA?
A paper came out yesterday, published in NATURE, peer-reviewed, entitled “N1-methyl Pseudouridylation of mRNA Causes +1 Ribosomal Frameshifting”.
Remember how mod RNA was formed from m RNA by converting uridine to pseudouridine, a modificaton which reduced inflammation but it made the RNA last for months instead of minutes to hours causing all kinds of problems because of the huge amounts of spike proteins that are formed and of course we all know now, the spike protein causes endotheliitis of the lining of our small blood vessels, clot formation leading to strokes and heart attacks, myocarditis, and enhances the actions of endotoxin which got into the vaccines because it comes from the cell walls of gram negative bacteria, endotoxin driving a more aggressive immune response, itself the essential pathophysiological avenue for spike protein damage?
Well that stupid modification, you know, the one that they didn’t leave enough time to test properly, the conversion of uridine to pseudouridine, the modification those woke imbeciles in Sweden gave the creators of which the Nobel prize in Medicine or Physiology for this year, the only Nobel in history that, thus far, was given for a modification that will kill millions more than it will save, THAT MODIFICATION?
Yes, that modification.
That modification also causes +1 Ribosomal Frame Shifting; one of the “not divisible by three” kinds of frameshifting; the real bad kind.
This means instead of all the proteins encoded in the mod RNAs (the spike proteins, the SV-40 promoters and enhancers, the other ones- it doesn’t matter what they are because they won’t get made in the mod RNAs that are +1 frame-shifted), we get gibberish proteins which means certain death to the cells that take in the lipid nanoparticles. But that happened when they made spike protein, didn’t it, because spike protein is non-self too, right?
Yes and that was a major screw-up by the designers at big Pharma, destroying all of the affected cells like that and causing the associated organ damage. But they claim it was a trade-off with all the antibodies that were produced to fight off that “horrible disease” (with an IFR of .1%” (same as the flu), now 1/10th of that…, i.e. “the biggest nothing burger to ever hit the airwaves” as I told Dr. B, The one that didn’t change the all cause mortality from the average of 2015 to 2019).
So we traded cell destruction for something that was supposed to give us a benefit(but didn’t because the whole thing was a nothing burger )for, in the best case, cell destruction because we are making gibberish proteins that don’t do anything but destroy the cell they were made in and make our immune systems go haywire (as the spike protein production did). In the worse case, we simply do not know yet. These things are going to be produced in the vaccine recipient’s cells forever because it looks like the DNA plasmids are making it into their cell nuclei (and is that why they put the SV-40 enhancers in the plasmids?)
Don’t pretty much all of our organs take in those lipid nanoparticles?
Yes, they do.
You might recall when I warned about this in my Dec 4, 2020 video, before the “vaccines” came out . I said, “what happens if these lipid particles get in the lymph or blood and go all over the body and the CD8 T killer cells wreak their havoc on those distant cells? I don’t mind losing a few deltoid cells but I don’t want to lose any heart or brain cells.” Oh yeah, we were assured they wouldn’t leave the arm by that professor at UC San Francisco School of Medicine and other so-called experts but they were all wrong.
What is the extent of the damage?
First, remember there are trillions of copies of mod RNA in every injection and that they go all over the body and get into all kinds of cells and organs. We just went over that.
Since, according to the paper, it is happening in 1/3 of the trillions of mod RNAs that went into and are going into people’s arms in each shot, random, bizarre, proteins- what they could do in the body in addition to causing the destruction of the cells they were made in, is anybody’s guess- are being produced in everyone who got the shot or shots in billions of their cells at least and will continue to do so until they die (thanks to Kevin McKernan’s work discovering the DNA contamination in the shots and sequencing it). There are 4284 nucleotides in the Pfizer BioNTech mod RNA vaccine. I don’t know where the frameshifting occurs, whether it occurs in some places more than others etc. but these and many other considerations are necessary to know if you want to determine how many different proteins could result from this process.
Looking at the numbers, there are trillions of cells in every recipient of both the Pfizer and Moderna jabs that are making randomly formed proteins. If the numbers of those random proteins are high enough, this alone seems to me to be a set-up for auto-immune disease and reminds me a lot of the mechanism by which we tell self from non-self (also described in my immunology primer).
Then we have to consider the odds that one of the random proteins actually has biological activity separate from the immune system havoc they are causing. What if one of these frameshifts results in the formation of a protein that blocks oxydative phosphorylation? It will kill you faster than cyanide. What if it catalyzes a reaction in the Krebs cycle in a way that it’s not supposed to be catalyzed? or messes up the delicate balance in calcium metabolism? The possibilities are endless.
I think Schwinn would recall their 10-speed bicycles if 1/3 were slipping gears, don’t you?
Dear FDA: For the fourth time since Labor Day, it’s time to recall these disastrous concoctions.
First Principles with Dr. Sheftall is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.